One of the most widely used school-based prevention programmes has proven to be effective in reducing drug use among adolescents in yet another country. After a team of researchers translated the programme known as Botvin LifeSkills Training into Italian, it was launched in around 180 schools in Lombardy, a region of Northern Italy. Within those schools the programme reached approximately 30,000 students and involved 1,800 teachers. The programme was found to reduce teenage smoking rates by 40% while boosting students’ self-esteem and equipping them with the relevant skills to deal with stressful situations. Following the success of the programme in Northern Italy, the Regional Observatory on Drug Addiction of Lombardy would like to see the programme implemented in schools across the country.