Barbiturates are synthetic drugs that used to be regularly prescribed for anxiety, depression and insomnia. However, they are highly dangerous because of the small difference between a normal dose and an overdose and many people were either accidentally dying or deliberately using them to commit suicide. Tolerance to barbiturates develops rapidly and the liability for harmful use or dependence is high. Patients who use these drugs over long periods can become psychologically and physically dependent, even though the prescribed dose is never exceeded.

Street names: Barbs, Block Busters, Christmas Trees, Goof Balls, Pinks, Red Devils, Reds & Blues, Yellow Jackets, Angels, Nembies, Chewies.