The term substance includes both drugs and other chemicals that, when used or taken, have an effect on the mind, brain or body. "Substances" is often used synonymously with the term "drugs" although it is more technically accurate and includes all psychoactive and pharmaceutical substances and medicines, the legal substance such as tobacco (nicotine) and alcohol, volatile substances (glue, inhalants) as well as the well known illegal substances such as cannabis, heroin, cocaine, amphetamines, ecstasy etc. The issue of concern is their use and misuse which can result in harm or become a major factor in health and social problems, problem behaviour, and physical suffering. The use of tobacco, alcohol and solvents are most common among young people and usually their first experience of drug use. Alcohol and tobacco cause more preventable health problems and premature death than any other drug.